ZHONGDONG ZHAO,KEVIN S. CURRIE,SEUNG H. LEE,JIANJUN XU,SCOTT A. MITCHELL,PETER A. BLOMGREN,JEFFREY E. KROPF,JENNIFER R. LO,AARON C. SCHMITT,JIN-MING XIONG,SUNDARAMOORTHI SWAMINATHAN
申请号：
PT14827669
公开号：
PT3087075T
申请日:
2014.12.22
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein R 1 , R 2 , R 3 , and R 4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
