#$%^&*AU2012200624A120120223.pdf#####ABSTRACT The invention discloses a method of identifying a gene associated with stage III primary cancer or lymph node metastasis. The genes so identified include CAVI, CST3, LIMKI, MMP2, MMP15, VEGF, ETV4, MMP9, PIK3C2B, and SERPINI. Also disclosed are methods for diagnosis, prognosis, and treatment of cancer. The invention further discloses compositions for preventing and treating diseases.