The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.本發明係關於通式(I)的4-甲基-2,3,5,9,9b-五氮雜-環戊[a]萘衍生物,其係磷酸二酯酶2及/或10之抑制劑,可用於治療中樞神經系統疾病及其他疾病。另外,本發明係關於製備醫藥組合物之方法及製造本發明化合物之方法。