The present disclosure provides systems and methods for predicting fluid responsiveness. Embodiments include sensors configured to obtain a high-resolution electrocardiogram signal and a computer system connected to the sensors, the computer system including a memory, a processor, and a display device. Computer system may be configured to receive the electrocardiogram signal from the sensors. Processor may be configured to detect and process changes in at least one of length, amplitude, slope, area, depth, and height of at least one of P, Q, R, S, T, and U complex of the electrocardiogram signal caused by the influence of physiological variables on each other to create a prognostic index. Processor may be further configured to analyze, quantify, and combine the prognostic index of the changes in the electrocardiogram signal and generate a fluid responsiveness prediction. Display device may display the results of the fluid responsiveness prediction.
