2-phenyl-N-(pyridine-hydroxymethyl) cyclopropane compounds, acryloyl choline acrylic choline receptor n-acrylonitrile modulator (PAMS)； pharmaceutical ingredients； and compounds for the treatment of specific diseases such as psychosis, schizophrenia, C disorder, etc. There are others.

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专利权人:

H. LUNDBECK A/S

发明人:

SAMS, ANETTE, GRAVEN,PÜSCHL, ASK,ESKILDSEN, JORGEN

申请号：

CL2013003744

公开号：

CL2013003744A1

申请日:

2013.12.27

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

The present invention relates to phenylcyclopropane carboxamide derivatives of formula (I) useful in therapy, to compositions comprising said compounds, and to their medical use. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ±7 receptor useful for the treatment of diseases and conditions such as schizophrenia, Alzheimers's, Parkinson's and epilepsy.COMPUESTOS DERIVADOS DE 2-FENIL-N-(PIRIDIN-HIDROXIMETIL)CICLOPROPANOCARBOXAMIDA, MODULADORES ALOSTÉRICOS POSITIVOS (PAMs) DEL RECEPTOR NICOTÍNICO DE ACETILCOLINA alfa7； COMPOSICIÓN FARMACÉUTICA； Y USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD SELECCIONADA ENTRE PSICOSIS, ESQUIZOFRENIA, TRASTORNOS COGNITIVOS, ENTRE OTROS.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/