Roman R. GANTA,Chuanmin CHENG,Arathy D. S. NAIR,Deborah JAWORSKI,Suhasini GANTA
申请号：
US15544090
公开号：
US20180021421A1
申请日:
2016.01.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens.
