This invention relates to a composition comprising a TLR2 moiety in solution, wherein the TLR2 moiety comprises a TLR2 agonist, for use in a method for treating or preventing a disease by raising an innate immune response in a subject, the method comprising administering to the subject an effective amount of said composition, and wherein the disease is not treated or prevented by a humoral or cellular immune response directed against the TLR2 moiety.本発明は、対象において先天性免疫応答を高めることにより疾患を治療又は予防する方法に関し、該方法は、溶液中にTLR2部分を含む有効量の組成物を対象に投与するステップを含み、TLR2部分はTLR2アゴニストを含み、疾患は、TLR2部分に対する液性免疫応答又は細胞性免疫応答により治療又は予防されない。【選択図】なし