The present invention relates to a glyoxalase fusion protein and a pharmaceutical composition containing the same, wherein the glyoxalase involved in active oxygen species metabolism is prepared as a fusion protein combined with a protein transport domain, thereby smoothly introducing into the cell, thereby preventing neurodegenerative diseases such as cerebral ischemia. It can be used as a preventive and therapeutic agent for diseases.Glyoxalase, fusion protein, cerebral ischemic injury, neuronal cell death본 발명은 글리옥살레이즈 융합단백질 및 이를 함유하는 약제학적 조성물에 관한 것으로서, 활성산소종 대사에 관여하는 글리옥살레이즈를 단백질수송도메인과 결합시킨 융합단백질로 제조함으로써 세포 내로 원활히 도입시켜 뇌허혈 등 신경퇴행성 질환의 예방 및 치료제로 이용할 수 있다.
