Concentrated polypeptide formulations with reduced viscosity

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专利权人:

GENENTECH INC.

发明人:

KAMERZELL TIM,WANG JOHN YUCHANG,MARTIN-MOE SHERRY

申请号：

NZ59851810

公开号：

NZ598518A

申请日:

2010.08.03

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Disclosed is a liquid formulation comprising (a) an antibody in an amount of greater than about 50 mg/mL and (b) dimethyl sulfoxide (DMSO) or dimethylacetamide (DMA) in an amount of between about 0.1% to about 50% v/v of the formulation, wherein the formulation has reduced viscosity compared to the same formulation in the absence of DMSO or DMA.

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中国工程科技知识中心

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