A heart valve prosthesis frame, the frame comprising a hollow tube shape for allowing blood to flow through； an upstream portion designed to expand to have at least one dimension wider than a native heart valve annulus； a downstream portion attached to the upstream portion, the downstream portion also designed to expand to have at least a portion with at least one dimension wider than the native heart valve annulus； wherein the downstream portion is shaped to have one side of the downstream portion of the hollow tube frame extend less from a center of the hollow tube than an opposite side of the hollow tube.
