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Stabilizer molecule-depleted albumin solution
专利权人:
Albutec GmbH
发明人:
Stange, Katrin
申请号:
AU2006245730
公开号:
AU2006245730B2
申请日:
2006.05.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to a method for producing an aqueous albumin solution froman albumin parent solution containing stabilizer molecules capable of occupyingbinding sites of the albumin. In order to increase the albumin binding capacityfor other molecules, at least a portion of the stabilizer molecules are removedfrom the albumin of the albumin parent solution and separated out from the albuminparent solution. In order to provide a method of this type, with which a stabilizedcommercial albumin parent solution can be prepared, in comparison to the priorart, easier, faster, and more economically and to prepare albumin without alteringit while removing a large portion of the stabilizers and while increasing thealbumin binding capacity, the method comprises the steps in which the albuminparent solution is brought into contact with a solid adsorber material whoseaffinity to at least a portion, preferably to all of the stabilizer moleculesused, is higher than the affinity of the albumin to the corresponding stabilizermolecules, and the albumin solution is separated out from the adsorber material,the method being carried out at a pH value >; 3.
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