JEJU NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Dong-sun LEE,Hack Sun CHOI
申请号：
US16341132
公开号：
US20200246307A1
申请日:
2017.10.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a composition for inhibiting the growth of cancer stem cells, which includes ciclesonide or a pharmaceutically acceptable salt thereof as an active ingredient, a pharmaceutical composition or food composition for inhibiting cancer metastasis, or treating or preventing cancer, which includes the composition, and the like. Ciclesonide of the present invention inhibits the growth of breast cancer cells and lung cancer cells, and inhibits the formation of breast cancer stem cells and lung cancer stem cells. In addition, it was confirmed that ciclesonide inhibited the expression of self-renewing genes such as Nanog, C-myc, Oct4, Sox2, Snail, and CD44, which are known to be characteristically expressed in breast cancer stem cells and lung cancer stem cells, inhibited the production of IL-6 and IL-8, which are known to be involved in the formation of mammospheres of breast cancer stem cells and the formation of tumorspheres of lung cancer stem cells, and inhibited the STAT3 signaling pathway. Accordingly, the compound inhibits the growth of cancer stem cells such as breast cancer stem cells, lung cancer stem cells, and the like and the growth of these cancers, and thus may be used for the treatment of cancer such as breast cancer, lung cancer, and the like.
