A formulation comprising a gene expression modifier selected from the group consisting of an oligonucleotide having any of SEQ ID No.:1 through SEQ ID No.:55. A method of treating a subject diagnosed with a pain disorder includes introducing into the subject's cerebrospinal fluid a composition comprising an oligonucleotide that reduces the concentration of Substance P in the subject's cerebrospinal fluid. A method of treating a subject diagnosed with a pain disorder includes introducing to a plurality of tender points of a subject a gene expression modifier that reduces the concentration of calcitonin gene-related protein in the subject's cerebrospinal fluid.
