Philippe Foubert;Sophie Le Ricousse-Roussanne;Jean-Sebastien Silvestre
发明人:
Philippe Foubert,Sophie Le Ricousse-Roussanne,Jean-Sebastien Silvestre
申请号：
US11996862
公开号：
US08338169B2
申请日:
2006.07.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A cell/ligand specific marking system, the system being characterized in that it comprises: (a) an endothelial precursor cell (EPC) including a cell marker selected from among the group consisting of the Eph (in particular EphB4 or EphB1), and (b) a protein material of structure L-K, which consists of a ligand (L) specific of the marker and is associated or fused with a binding protein (K), the system being capable of providing a proangiogenetic cell material of structure EPC-Eph-L-K. The invention also concerns the cell material as product capable of stimulating angiogenesis, its preparation method and its therapeutic use, in particular with respect to vascular insufficiencies.
