Disclosed herein are quinoline compounds of formula I, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful in the treatment or prevention of a disease or condition caused, exacerbated by or resulting from an excess of, or undesired activation of, platelets in a patient, as such is useful for treating essential thrombocythemia, polycythemia vera, restenosis, perioperative antiplatelet therapy and device-associated thrombi and also small cell lung cancer. Examples of particularly preferred compounds include: 6-(1-(Benzo[d]thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroquinolin-7-yl)-3-(3-(4-(dimethylamino)phenoxy)propoxy)picolinic acid 2-(1-(benzo[d]thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroquinolin-7-yl)thiazole-4-carboxylic acid； 6-(1-(benzo[d]thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroquinolin-7-yl)-3-hydroxypicolinic acid； 6-(4-(benzo[d]thiazol-2-ylcarbamoyl)-1-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl)picolinic acid； 6-(1-(benzo[d]thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroquinolin-7-yl)-3-(1-benzyl-1H-pyrazol-4-yl)picolinic acid； (E)-2-(1-(benzo[d]thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroquinolin-7-yl)-5-(prop-1-enyl)thiazole-4-carboxylic acid； 5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(4-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thiazole-4-carboxylic acid.
