Santiago Vaillard,Marianela Gonzalez,Ricardo José Antonio Grau
申请号：
US13805113
公开号：
US20130303799A1
申请日:
2011.05.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A a method for producing activated linear polymers and activatable branched polymers thereof, is carried out by a) reacting a linear nonpeptidic activatable polymer, chemically blocked at one end, with an azole ring activating group that provides a leaving group to produce an intermediate polymer of the general formula poly-lm； b) reacting said poly-lm with an alkylating agent to form an imidazolium salt of the general formula poly-1m+(alkyl)X-； and c) reacting said poly-lm +(alkyl)X with a linker molecule bearing at least two nucleophilic moieties to produce an activatable branched polymer derivative thereof. In some embodiments “poly” is a polymer selected from the group consisting of poly(alkylene oxides), poly(oxyethylated polyols), poly(olefinic alcohols), and polymers of alkylene oxide and propylene oxide； in some embodiments “Im +” is an imidazolium ion； and in some embodiments “X-” is an anionic counterion.
