Compounds are described that selectively modulate the sphingosine-1-phosphate receptor, including compounds that modulate the S1P receptor subtype 1. Methods for the chiral synthesis of such compounds are described. Uses, methods of treatment or prophylaxis and methods for preparing the compositions of the invention, including the compounds of the invention for the treatment or prevention of diseases, malignant conditions and disorders for which sphingosine-1-phosphate receptor is medically described, are described.Buluş, sfingozin 1-fosfat reseptör alt tip 1'in agonistleri olan bileşikler, bunların sentez yöntemleri ve bunların terapötik ve/veya profilaktik kullanım yöntemleri ile ilgilidir.
