QU, XIN,GRUENING, RAINER,MERRITT, KAREN,CHEN, PAUL N.,FALEVICH, VITALY
申请号：
CA2636975
公开号：
CA2636975C
申请日:
2007.01.16
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Surface-active, non-leaching antimicrobial film forming compositions andmethods for their application to preferably medical device surfaces areprovided. The compositions form durable coatings with long-lastingantimicrobial efficacy without formation of a zone of inhibition. Optionallythe films can be hydrophilic. Specific long-chain molecules of certainchemical reactivity are covalently bonded into a polymeric matrix. Theymaintain a long-term anti-microbial efficacy without being leached out intothe aqueous environment. The polymeric matrix of the compositions containfunctional groups, which covalently bond to an amine, thiol, carboxyl,aldehyde or hydroxyl active group of selected long chain quaternary ammoniumcompounds. Upon formation of a covalent bonding with the polymeric matrix thelong chain compounds become immobilized but still maintain antimicrobialefficacy. They do not leach out over extended period of time into the aqueousenvironment and maintain an anti-microbial efficacy against microorganisms.The coating is useful to prevent bacterial colonization on a variety ofsurface including surfaces of medical devices.
