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METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
专利权人:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人:
DAVIDSON, BEVERLY L.,LEE, JOHN H.
申请号:
CA2971687
公开号:
CA2971687A1
申请日:
2015.12.30
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mTORCl function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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