METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES

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专利权人:

UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人:

DAVIDSON, BEVERLY L.,LEE, JOHN H.

申请号：

CA2971687

公开号：

CA2971687A1

申请日:

2015.12.30

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mTORCl function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/