A long bone screw for a minimally invasive surgery contains a body including a holder, and the holder has two opposite first fences and two opposite second fences extending upwardly from the two opposite first fences each second fence has a length extending out of a muscle tissue, the length of each second fence is within 6 to 12 cm and the two opposite second fences one piece extend from the two opposite first fences, such that a fixing position of skeleton is marked clearly, and a size of a surgery wound is reduced.