PROBLEM TO BE SOLVED: To provide a pharmaceutical composition having a P2X7 receptor inhibitory action and useful for the treatment of a pain or the like.SOLUTION: The present invention provides a pharmaceutical composition containing a compound represented by formula (I) (Z1 is C(R4) or the like； R4 is H or the like； Z2 is C(R5a)(R5a') or the like； a dashed line is the existence or absence of a bond； if the dashed line denotes the existence of a bond, R5a' is absent； R5a and R5a' independently represent H or the like； ring Q is a substitutable, 5-membered, non-heteroaromatic ring or the like； Y1 is O or the like； R2a is formula:-(C(R2a')(R2b'))n-R1； R2b is H or the like； R2a' and R2b' independently represent H or the like； R1 is a substitutable, aromatic carbocyclic group or the like； X is N(R7a) or the like； R7a is H or the like； R3 is a substitutable, aromatic carbocyclic group or the like； n is an integer of 0-4； m is an integer of 0-4).SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】Ｐ２Ｘ７受容体阻害作用を有し、疼痛等の治療に有用な医薬組成物の提供。【解決手段】式（Ｉ）で表される化合物を含有する医薬組成物。（Ｚ１はＣ（Ｒ４）等；Ｒ４はＨ等；Ｚ２はＣ（Ｒ５ａ）（Ｒ５ａ’）等；破線は、結合の存在又は不存在を示し；破線が結合の存在を表すとき、Ｒ５ａ’は存在せず；Ｒ５ａ及びＲ５ａ’は各々独立にＨ等；環Ｑは置換可５員非芳香族複素環等；Ｙ１はＯ等；Ｒ２ａは式：－（Ｃ（Ｒ２ａ’）（Ｒ２ｂ’））ｎ－Ｒ１；Ｒ２ｂはＨ等；Ｒ２ａ’及びＲ２ｂ’は各々独立にＨ等；Ｒ１は置換可芳香族炭素環式基等；ＸはＮ（Ｒ７ａ）等；Ｒ７ａはＨ等；Ｒ３は置換可芳香族炭素環式基等；ｎは０～４の整数；ｍは０～４の整数。）【選択図】なし
