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COMPOSÉS PYRIMIDONE UTILISÉS COMME INHIBITEURS DE LA LP-PLA2 ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES
专利权人:
Shanghai Institute Of Materia Medica Chinese Academy of Sciences
发明人:
SHEN, Jianhua,WANG, Yiping,CHEN, Xinde,XU, Wenwei,WANG, Kai
申请号:
EP15871995
公开号:
EP3239135A4
申请日:
2015.12.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to pyrimidone compounds used as Lp-PLA 2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R 1 , R 2 , R 3 , X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA 2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA 2 enzyme.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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