CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DE BOURGOGNE DIJON;UNIVERSITE DE CERGY PONTOISE
发明人:
Débora D'Addona,Claire Bernhard,Anna Maria Rovero,Franck Denat,Michael Chorev,Débora DAddona
申请号：
US14365875
公开号：
US20140314670A1
申请日:
2012.12.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relate to the new conjugated somatostatin analogs of formula (I), wherein A- is H or TAG-B—, wherein —B— is 0 or a spacer, wherein TAG is a chelating agent (e.g. DOTA), a fluorescent dye, (e.g. Bodipy-B derivative, a Rho-damine-B derivative, a Fluorescein-B derivative, a Cyanine-B derivative, a Porphyrin-B derivative), a bimodal agent, or a cytotoxic agent (e.g. a doxorubicin derivative) wherein R1 is CI-C4 alkynyl radical when R2 is CI-C4 azido radical and viceversa and methods for preparing same, pharmaceutical compositions comprising them and their use in imaging and the treatment of cancer.
