The invention relates to a liquid gas sterilization device, which comprises: a spray bottle, a body and a nozzle, a holding space in the body and an opening on one side; the nozzle is arranged on the opening of the holding space to open and close the opening; the nozzle is provided with a nozzle, which can atomize and spray the liquid in the holding space through the nozzle; and A sterilizing unit is arranged outside the spray bottle, which can slowly release chlorine dioxide gas; a sterilizing liquid is arranged in the holding space of the spray bottle.The liquid gas sterilization device can spray the sterilizing liquid through the spray gun at a specific position for disinfection and sterilization, and the sterilization unit can produce disinfection and sterilization effect on the air around the spray bottle, and the sterilization effect can be improved.本創作係與一種液氣滅菌裝置有關,包含有:一噴瓶,具有一本體及一噴頭,該本體內設置一容置空間,一側設有一開口;該噴頭,設置於該容置空間之開口上,可開啟及閉合該開口,該噴頭具有一噴口,該噴頭可將該容置空間內的液體透過該噴口霧化噴出;一固態的滅菌單元,設於該噴瓶外,其可緩慢釋出二氧化氯氣體;一滅菌液體,設於該噴瓶之容置空間內。該液氣滅菌裝置可以透過該噴槍噴灑該滅菌液體於特定的位置進行消毒滅菌,並且該滅菌單元可以對於噴瓶周邊的空氣產生消毒滅菌的作用,而可提升其滅菌效果。