This invention covers anti-cancer or oncogene switching therapeutics that employ sequence-specific nucleic acid decoys for competitive binding of transcription factors. These nucleic acid decoys can competitively bind to transcription factors regulating the expression of oncogenes including CREB, JUN/FOS, JUN/ATF and MYC/MAX in the cell, leading to the inhibition of tumor cell growth. As a result, they can be developed into anti-cancer therapeutic drugs.
