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Biomarkers of Response to Inhibition of Poly-ADP Ribose Polymerase (PARP) in Cancer
专利权人:
发明人:
Dennis Slamon,Richard Finn,Dylan Conklin
申请号:
US14899974
公开号:
US20160138114A1
申请日:
2014.06.18
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene amplification of a CHD1L gene or an RTEL1 gene in a tumor sample from the subject. Further provided are methods of treating a tumor with a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a subject by administering an effective dose of a PARP inhibitor.
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