PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for preventing, improving or treating the neurologic manifestations of premenstrual dysphoric disorder and/or premenstrual syndrome, or at least one symptom accompanying to the neurologic manifestation.SOLUTION: The present invention provides a pharmaceutical composition using in combination with as an active ingredient at least one selected from pyridoxamine and a pharmaceutically acceptable salt thereof, or at least one selected from a pyridoxamine compound and thiamine as well as a derivative thereof and pharmaceutically acceptable salts thereof. The administration method of a pyridoxamine-containing composition whose dosage is 300 mg or more daily in terms of the amount of pyridoxamine is also provided.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】月経前不快気分障害及び/又は月経前症候群の精神症状又は当該精神症状に付随する症状の少なくとも1つを予防、改善又は治療するための医薬品組成物の提供。【解決手段】ピリドキサミン、及びその薬学的に許容される塩から選択される少なくとも一種、又はピリドキサミン化合物とチアミン、その誘導体、及びそれらの薬学的に許容される塩から選択される少なくとも一種とを組み合わせて有効成分とする医薬組成物。1日の投与量がピリドキサミンの量に換算して300mg以上であるピリドキサミン含有組成物の投与方法。【選択図】なし
