With what light Move power Treatment Fa He the photosensitive Elixirs of tetrapyrrole that the B Ring of Swollen tumor imaging is oxidized by It original-D Ring
HEALTH RESEARCH, INC.;健康研究有限公司; INC.;HEALTH RESEARCH
发明人:
Ravindra K. PANDEY,拉文德拉．K．潘迪,Chao LIU,刘超,劉超,Mahabeer, DOBHAL,马哈比尔．多哈尔,馬哈比爾．多哈爾,William POTTER,威廉．波特,Janet MORGAN,珍妮特．莫根,Allan OSEROFF,埃兰．奥斯洛夫,埃蘭．奧斯洛夫,拉文德拉.K.潘迪,马哈比尔.多哈尔,馬哈比爾.多哈爾,威廉.波特,珍妮特.莫根,埃兰.奥斯洛夫,埃蘭.奧斯洛夫
申请号：
MOJ002474
公开号：
MOJ002474B
申请日:
2017.01.12
申请国别(地区):
MO
年份:
2017
代理人:
摘要：
This Hair Ming Gong Open photosensitive Elixirs of mono- Seed tetrapyrrole and imaging Elixirs compound, the compound have with A, B, C and D Ring , And by the B Ring of It original and the D Ring being oxidized. Gifted Election compound has thick He Xi System with the not Eat and carbon atom Office of at least 95% Pure Du , And Gifted Election C Ring With D Ring most O close not Eat and carbon atom Office and C With D Ring Inter. The bright It of this Hair includes the method for compound described in the Shou Shuai System Prepare of the Chao Over 95% of Yi, the Si pyrrolesization He Wu Open that the method From B and D Ring are oxidized begins, in its molten Elixirs of Rong Xie Halogen Dai Hydrocarbon of Will And Will its with the nitroparaffin solution Office of the FeCl3.6H2O of foot Enough reason to obtain the You Machine Layer And universe with Will D Ring oxidation , Fen From dry.本發明公開了一種四吡咯光敏劑和成像劑化合物，所述化合物具有A、B、C和D環，並具有被還原的B環和被氧化的D環。優選化合物具有至少95％的純度，並優選C環的與D環最鄰近的不飽和碳原子處和C與D環之間的不飽和碳原子處具有稠合系統。本發明還包括了以超過95％的收率製備所述化合物的方法，所述方法從B和D環被氧化的四吡咯化合物開始，將其溶解在鹵代烴溶劑中，並將其用足夠的FeCl3．6H2O的硝基烷溶液處理以將D環氧化，分離得到的有機層並乾燥。
