A dialysis system (10a) includes: a dialysis fluid pump receptacle (64)actuated by a dialysis fluid pump actuator; adialysis fluid line (70); a blood filter (40) in fluid communication with thedialysis fluid pump receptacle via the dialysis fluid line;an extracorporeal circuit (16); a blood pump receptacle (30a, 30b) actuated bya blood pump actuator and in fluid communicationwith the blood filter via the extracorporeal circuit; and a control unit (50)that (i) in a first treatment pumps peritoneal dialysis fluidthrough the dialysis fluid pump receptacle, the dialysis fluid line, the bloodfilter, the extracorporeal circuit and the blood pumpreceptacle to the patient's peritoneum operating the dialysis fluid pumpactuator and the blood pump actuator at a first pressure, and(ii) in a second treatment pumps blood through the extracorporeal circuit, theblood pump receptacle and the blood filter operatingthe blood pump actuator at a second, different pressure.