The present invention provides Relaxin fusion proteins, wherein a linker connects the carboxy-terminus of Relaxin with a proteinaceous half-life extending moiety and the linker comprises a protease cleavage site. Therefore, the invention provides Relaxin fusion polypeptides with extended half-life whereby the fusion protein by itself serves as a depot for release of the biologically active Relaxin. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, cells expressing the Relaxin fusion polypeptides, pharmaceutical compositions and medical use of such fusion polypeptides.本發明提供鬆弛素融合蛋白，其中一連接子將鬆弛素之羧基端與一延長半衰期之蛋白部分相連結，且該連接子包括一蛋白酶切割位點。因此，本發明提供具有半衰期延長之鬆弛素融合多肽，藉此該融合蛋白本身充作用以釋放具有生物活性之鬆弛素的貯庫。此外，本發明提供編碼前述融合多肽之核酸序列、含有該核酸序列之載體、表現該鬆弛素融合多肽之細胞、此等融合多肽的醫藥組成物以及醫藥用途。
