A probe cover for medical thermometer has a matching feature for preventingits use with an incompatible thermometer.A mechanical matching feature of the probe cover includes at least one of afold, a step, or a series of holes or indentationsthat are respectively matched to a ridge, a valley or series of pins formed onthe front end of a compatible thermometer.When applied to the compatible thermometer, the mechanical matching featurepermits the probe cover to be fully seated on andretained by the probe, thereby placing the thermometer in condition for use.Alternatively, an opto-electronic matching feature ofthe probe cover includes a reflective layer for use with an opto-electronicdetection circuit of a compatible thermometer. When appliedto the compatible thermometer, the opto-electronic detection detects thereflective layer and places the compatible thermometerin an operational state for use.