Formulations of comprising a neuroactive steroid, e.g., allopregnanolone; and optionally a cyclodextrin, e.g., a ß-cyclodextrin, e.g., a sulfo butyl ether ß- cyclodextrin, e.g., a ß-cyclodextrin, e.g., a sulfo butyl ether ß-cyclodextrin, e.g., CAPTISOL®; and methods of use in treating CNS disorders.