THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, &； THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY;IMPERIAL INNOVATIONS LTD.;DUKE UNIVERSITY
发明人:
Peter HUMPHRIES,Marian HUMPHRIES,Matthew CAMPBELL,Anna-Sophia KIANG,Daniel STAMER,Darryl Ray OVERBY,Chi Shing Lawrence TAM
申请号：
US16099153
公开号：
US20190376065A1
申请日:
2017.04.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.
