SPROGOE, KENNETT,RAU, HARALD,CLEEMANN, FELIX,HERSEL, ULRICH,RASMUSSEN, CAROLINE ELISABETH
申请号：
CA3007982
公开号：
CA3007982A1
申请日:
2017.01.05
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to a controlled-release CNP agonist from which CNP agonist is released with a release half-life of at least 6 hours under physiological conditions and which controlled-release CNP agonist has an EC50 that is at least 20-fold higher than the EC50 of the corresponding free CNP agonist and which released CNP agonist has an EC50 that is at most 3-fold higher than the EC50 of the corresponding free CNP agonist； to pharmaceutical compositions comprising said controlled-release CNP agonist； their use； and to methods of treatment.
