The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R1—XZXZNXZX—R2, wherebyN is a whole number between 3 and 7, preferably 5,X is a positively charged natural and/or non-natural amino acid residue,Z is an amino acid residue selected from the group consisting of L, V, I, F and/or W, andR1 and R2 are selected independantly one from the other from the group consisting of —H, —NH2, —COCH3, —COH, a peptide with up to 20 amino acid residues or a peptide reactive group or a peptide linker with or without a peptide； X—R2 may also be an amide, ester or thioester of the C-terminal amino acid residue,as well as the use of said peptide for the preparation of an adjuvant for enhancing the immune response to at least one antigen.
