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CONJUGUES DE MEDICAMENT A FAIBLE POIDS MOLECULAIRE SERVANT A LA LIAISON A L'ANHYDRASE IX CARBONIQUE
专利权人:
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
发明人:
KRALL, NIKOLAUS,DECURTINS, WILLY,NERI, DARIO,SCHEUERMANN, JORG,WICHERT, MORENO
申请号:
CA3008111
公开号:
CA3008111C
申请日:
2015.02.03
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
A targeted therapeutic agent comprising a compound of formula (I): B-L-D, wherein: B is a low molecular weight binding moiety for Carbonic Anhydrase IX (CAIX); D is a drug moiety; and L is a linker group that undergoes cleavage in vivo for releasing said drug moiety in an active form. The drug moiety is suitably a cytotoxic agent for targeted delivery to cancer cells expressing CAIX. The binding moiety B suitably comprises a sulfonamidothiadiazole moiety. The binding moiety B may comprise one, two or more groups capable of binding to CAIX. The linker group suitably comprises a disulfide bond and/or a triazole group and/or a cleavable peptide group.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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