To provide a macrolide compound-containing composition that hardly gives a feel of bitterness even when taken in such a dosage form that normally would give a feel of bitterness, and a method for producing the same.SOLUTION: The present invention provides an agent for inhibiting the bitterness of a macrolide compound containing cyclodextrin and/or a derivative thereof as an active ingredient； and a method for producing a macrolide compound-containing composition that includes the step of mixing a macrolide compound with cyclodextrin and/or a derivative thereof in a solvent to obtain a macrolide compound-containing solution with reduced bitterness.SELECTED DRAWING: None【課題】通常は苦味を感じやすい剤形で服用しても、苦味を感じにくいマクロライド化合物含有組成物及びその製造方法の提供。【解決手段】シクロデキストリン及び／又はその誘導体を有効成分として含む、マクロライド化合物の苦味抑制剤。マクロライド化合物とシクロデキストリン及び／又はその誘導体とを溶媒中で混合して、苦味を低減させたマクロライド化合物含有溶液を得る工程を含む、マクロライド化合物含有組成物の製造方法。【選択図】なし
