Inhaler device (1) of a powdered substance contained in a capsule (2) of the type having a cover formed of two parts, comprising: - a seat capsule (14) suitable for receiving the capsule (2), said seat capsule made of two parts (14 ') may be separated each other, with each seat portion capsule (14') being suitable for retaining a capsule part (2 ') respectively, - separating means (40), operable to cause the distancing of said two parts seat capsule (14 ') and comprising at least one wedge (42), - an inhaler body (10) in which is defined the seat capsule ( 14), - a nozzle (12) which is removably coupled to the inhaler body (10) having an upper portion (16) defining an outlet passage (18) in fluid communication with said seat capsule (14) and a base (20) which engages the inhaler body (10); the separation means carried on said nozzle base, the inhaler body (10) having an end wall (27) and a pair of resilient arms (28) extending vertically from said end wall and having being surfaces parallel respective fork (30) and facing each other, each seat portion capsule (14 ') coupled in the upper part of a resilient arm respective (28) being, said element being wedge-shaped (42) suitable to be inserted between said surfaces (30) to cause the fork spring arms (28).Dispositivo inhalador (1) de una sustancia en polvo contenida en una cápsula (2) del tipo que tiene un opérculo formado de dos partes, que comprende: - un asiento de cápsula (14) adecuado para recibir la cápsula (2), estando dicho asiento de cápsula fabricado en dos partes (14') que pueden estar separadas recíprocamente, con cada parte de asiento de cápsula (14') siendo adecuado para retener una parte de cápsula (2') respectiva, - medios de separación (40), operables para provocar el distanciamiento de dichas dos partes de asiento de cápsula (14') y que comprende al menos un elemento en forma de cuña (42), - un cuerpo de inhalador (10) en el que se define el asiento de cápsula (14), - una boquilla (12), que se acopla