The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.本發明涉及對哺乳動物B7-H3受體且更具體而言對人B7-H3受體具有免疫反應性的抗體及其片段,並涉及它們的用途,特別是在癌症和炎症的治療中的用途。本發明因此具體地涉及人源化B7-H3反應性抗體及其免疫反應性片段,該抗體及其免疫反應性片段能夠介導、且更佳地增強免疫系統針對與多種人癌症相關的癌細胞的活化。BRCA84D‧‧‧融合瘤SEQ ID No:3‧‧‧可變輕鏈的胺基酸序列SEQ ID No:68‧‧‧可變輕鏈SEQ ID No:11/SEQ ID No:80‧‧‧可變重鏈的胺基酸序列
