Antiviral combinations involving (4r,12as)-n-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2hpyrido[1&rsquo,2&rsquo:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

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专利权人:

VIIV HEALTHCARE COMPANY

发明人:

UNDERWOOD MARK RICHARD

申请号：

NZ62782411

公开号：

NZ627824A

申请日:

2011.01.24

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed are combinations of the compound of formula I (4R,12aS)-N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1&rsquo,2&rsquo:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (also known as dolutegravir and GSK1349572) and rilpivirine (TMC-278) or a pharmaceutically acceptable salt thereof. Also disclosed is the use of the combination in the manufacture of a medicament for the treatment of HIV infection.

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