Shanghai Hengrui Pharmaceutical Co. Ltd.;Jiangsu Hengrui Medicine Co., Ltd.
发明人:
申请号:
EP17746993.9
公开号:
EP3412688A4
申请日:
2017.02.03
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
Provided are a thrombin antibody, an antigen-binding fragment and a pharmaceutical use thereof. Further provided are a chimeric antibody and a humanized antibody comprising a thrombin antibody CDR region, and a pharmaceutical composition comprising the thrombin antibody and the antigen-binding fragment thereof, as well as the use thereof as an anticoagulant drug. In particular, provided is a use of the humanized thrombin antibody in preparing a drug for treating a thrombin-mediated disease or condition.