MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人:
TOM WÖRDEN, Henrik,HORNUNG, Daniel,BAIG, Tariq
申请号：
EPEP2017/082048
公开号：
WO2018/127358A1
申请日:
2017.12.08
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
An apparatus (1 ) for terminating or unpinning rotating electric activity (2) in a cardiac tissue (3), the apparatus (1 ) comprises an electric state sensor sensing at least one electric parameter of the cardiac tissue； an electric state analyzer (9) connected to the electric state sensor (8) and analyzing the at least one electric parameter for rotating electric activity (2) in the cardiac tissue (3)； a pulse generator (19) connected to the electric state analyzer (9) and generating electric pulses in response to rotating electric activity (2) in the cardiac tissue (3)； and a pulse applicator (20) connected to the pulse generator (19) and applying the electric pulses as electric field pulses extending across the cardiac tissue (3). The electric pulses include a rotating electric activity termination or unpinning pulse (28) and a plurality of rotating electric activity synchronization pulses (27) preceding the rotating electric activity termination or unpinning pulse (28). The rotating electric activity synchronization pulses (27) are arranged at first intervals (Tsync), and the rotating electric activity termination or unpinning pulse (28) is arranged at a second interval (At) in a range from 0.7 to 1.2 times one of the first intervals (Tsync) after the last one of the plurality of rotating electric activity synchronization pulses (27). At least one of a first maximum electric field strength (FSsync) as caused by each of the rotating electric activity synchronization pulses (27) and a first electric pulse energy (PEsync) delivered to the cardiac tissue (3) by each of the rotating electric activity synchronization pulses (27) is not more than 82 % of a second maximum electric field strength (FStou) as caused by the rotating electric activity termination or unpinning pulse (28) or not more than 67 % of a second electric pulse energy (PEtou) delivered to the cardiac tissue (3) by the rotating electric activity termination or unpinning pulse (28), respectively.l'invent
