ROBERT M. JONES,JUERG LEHMANN,DANIEL J. BUZARD,BRETT ULLMAN,SUN HEE KIM,XIUWEN ZHU,SANGDON HAN,JEANNE V. MOODY,SCOTT STIRN
申请号：
PT09788983
公开号：
PT2326621T
申请日:
2009.07.22
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia): and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.
