JUNG, Françoise,OBRECHT, Daniel,LÖWE, Ralf,ZIMMERMANN, Johann,LEMERCIER, Guillaume,CHEVALIER, Eric
申请号：
ES12768803
公开号：
ES2576959T3
申请日:
2012.10.02
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of general formula (I) cyclo [P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-P13-P14-T1-T2] (I) in which individual elements T or P are connected in any direction from the point of attachment to the carbonyl (C> = O) to nitrogen (N) of the next element and in which T1 is a D α-amino acid naturally occurring or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain T1 is an L α-naturally occurring amino acid or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain P1, P3, P12, P13 and P14 are independently Gly or L α-amino acid naturally occurring or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain P2, P5 and P8 are independently an aromatic amino acid L-α natural or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain P4 and P11 are L α-amino crosslinkers natural or unnatural each containing in total 1 to 12 carbon atoms and / or heteroatoms in a simple side chain, together, are joining P4 and P11 through covalent interactions or electrostatic P6 is Gly P7 is a D α-amino acid naturally occurring or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain P9 is an L α-amino alcohol of natural or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain and P10 is an L α-amino aliphatic naturally occurring or unnatural containing in total 1 to 25 carbon atoms and / or heteroatoms in a simple side chain or a tautomer or rotomer thereof, or a salt, or a hydrate or solvate thereof.Compuesto de la fórmula general (I), ciclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-P13-P14-T1-T2] (I) en la que los elementos individuales T o P están conectados en cualquier dirección desde el punto de unión al carbonilo (C >= O) al nitrógeno (N) del elemento siguiente y en la que T1 es un D α-aminoácido de origen natural o no natural que contiene en tot
