ARTAVANIS-TSAKONAS, SPYRIDON,FORTINI, MARK E.,MATSUNO, KENJI
申请号：
CA2233534
公开号：
CA2233534C
申请日:
1996.09.27
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notchfunction, by inhibiting the differentiation of the cells without inhibitingproliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem orprogenitor cells. These expanded cells can be used in cell replacement therapyto provide desired cell populations and help in the regeneration of diseasedand/or injured tissues. The expanded cell populations can also be maderecombinant and used for gene therapy, or can be used to supply functionsassociated with a particular precursor cell or its progeny cell.
