monoclonal antibody or binding fragment, isolated nucleic acid molecule, vector, host cell, methods for preparing the monoclonal antibody or binding fragment in vivo or in vitro and for prevention and / or treatment and / or adjuvant therapy and / or diagnosis of a tumor, conjugate, kit, use of a monoclonal antibody or binding fragment, and pharmaceutical composition?
BAIYONG LI,PENG ZHANG,XINGHUA PANG,YU XIA,ZHONGMIN WANG
申请号：
BR112017002080
公开号：
BR112017002080A2
申请日:
2015.07.31
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention belongs to the fields of tumor treatment and molecular immunology and provides an anti-ctla4 monoclonal antibody or antigen binding fragment thereof, a medicinal composition thereof and a use thereof. The monoclonal antibody of the present invention prevents clta4 from binding to b7, thereby eliminating the immunosuppressive effect of ctla4 in the host and activating t lymphocytes.a presente invenção pertence aos campos de tratamento de tumor e imunologia molecular e fornece um anticorpo monoclonal anti-ctla4 ou um fragmento de ligação ao antígeno do mesmo, uma composição medicinal do mesmo e um uso do mesmo. o anticorpo monoclonal da presente invenção impede que clta4 se ligue à b7, eliminando, assim, o efeito imunossupressor de ctla4 no hospedeiro e ativando linfócitos t.
