GLINIAK, BRIAN,YANG, XIAO-DONG,WONG-MADDEN, SHARON,FOLTZ, IAN,FENG, XIAO,FITCH, ALISON,FOSTER, STEPHEN,KETCHEM, RANDALL R
申请号：
NZ56639406
公开号：
NZ566394A
申请日:
2006.08.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an isolated antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises CDR1 having amino acids 26 to 37 of SEQ ID NO: 30, CDR2 having amino acids 52 to 67 of SEQ ID NO: 30, and CDR3 having amino acids 100 to 111 of SEQ ID NO: 30, wherein the light chain comprises CDR1 having amino acids 24 to 35 of SEQ ID NO: 64, CDR2 having amino acids 51 to 57 of SEQ ID NO: 64, and CDR3 having amino acids 90 to 98 of SEQ ID NO: 64, and wherein the antibody binds TRAIL receptor-2 (TR-2). Also disclosed is the use of the antibody in the manufacture of a medicament for treating cancer in a patient.
