The invention described herein, when implemented on a processor, uses CNA-guided care to improve the clinical outcome at a particular patient level and reduce total treatment costs at a population level in a first COTA module. Provided are non-transitory computer-readable media, methods, and systems for storing computer program instructions for execution. By proactively accounting for biological variability by grouping patients within a patient population to a first clinical outcome tracking and analysis module on a processor with a first clinical outcome tracking and analysis module, thereby , Remove biological variability as a factor in the value of treatment, and leave treatment variability as a controlling factor in treatment outcome, which receives and collects personal health information from each patient in the patient population and The latter is done by generating and assigning multiple clinical outcome and analysis Nodal Addresses (CNAs) within the first clinical outcome tracking and analysis module, each CNA being , Sorted and categorized information as a sequence of discrete punctuation digits, including a prefix, a middle part, and a suffix, representing a preselected set of variables that divides into a clinically relevant set of health information. A first clinical outcomes tracking and analysis (COTA) module tracks the outcome of treatment selection and reports on outcomes associated with the use of CNAs. CNA guided care has two aspects, operates through the application of CNAs, and is formed by a triad of healthcare providers, payers, and patients suffering from a disease. The first aspect, an activation tool, includes a healthcare provider, a computer including a processor with a first clinical outcome tracking and analysis (COTA) module, and a first communicatively linked to the first COTA module via a network. It includes the interaction between the first client device with the 2COTA module and the payer. The payer comprises, through a second COT
