Implantable matrices are provided that include at least one therapeutic agent having hemostatic and antimicrobial activity. The implantable matrices are configured to be implanted into a hone defect. The implantable matrices aid in reducing operative and post-operative bleeding and inhibiting microbial growth. In some embodiments, the matrices provided include therapeutic agent(s) having hemostatic and antimicrobial activity that do not compromise the bioactivity of the matrix to induce or permit new tissue growth.
