One aspect of the present disclosure relates to a closed loop therapy system for treating post-traumatic stress disorder (PTSD) in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing can be configured to detect at least one physiological parameter associated with PTSD. The delivery component can be configured for implantation on or about a pre-determined spinal simulation site. The pre-determined spinal stimulation site can include a spinal cord segment, or spinal nervous tissue associated therewith, other than a C1-C3 spinal cord segment or spinal nervous tissue associated therewith. The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component to modulate activity at the pre-determined spinal stimulation site to effectively treat PTSD in the subject.
